Price L A, Goldie J H, Hill B T
Br Med J. 1975 Apr 5;2(5961):20-1. doi: 10.1136/bmj.2.5961.20.
Methodichlorophen was given to 26 patients with terminal malignant disease. Eight patients received adequate doses, and five of them showed objective evidence of tumour regression while three failed to respond. Those who responded included four out of five patients with lung cancer (three with squamous-cell carcinoma and one with oat-cell carcinoma) and a patient with hypernephroma. Two patients with testicular teratomas and one with acute myeloid leukemia failed to respond. The drug may be given safely by mouth to outpatients if certain precautions are taken.
对26例晚期恶性疾病患者给予甲氧氯苯。8例患者接受了足量药物治疗,其中5例有肿瘤消退的客观证据,3例无反应。有反应的患者包括5例肺癌患者中的4例(3例鳞状细胞癌和1例燕麦细胞癌)以及1例肾上腺样瘤患者。2例睾丸畸胎瘤患者和1例急性髓细胞白血病患者无反应。如果采取某些预防措施,该药物可安全地口服给门诊患者。