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[大脑皮质中交叉反应性胸腺和脑抗原的存在]

[Presence of cross-reacting thymus and brain antigens in the cerebral cortex].

作者信息

Belokrylov G A, Zhitnukhin Iu L, Sofronov B N

出版信息

Biull Eksp Biol Med. 1976 Jul;82(7):834-6.

PMID:953347
Abstract

Rabbit antisera against antigens of mouse, rabbit, guinea pig and human whole brain cross-reacted in the cytotoxic test with the lymphocytes of the thymus, lymph nodes and the spleen of these animal species. Mouse thymocytes were most sensitive to the antibrain sera (cytotoxic index -- 63--100 per cent); cells from other mouse lymphoid organs and lymphocytes of rabbit, guinea pig and man were more resistant. Bone marrow lymphocytes were not damaged by any of these sera. The antigens which induced the cytotoxic properties of the sera were found only in the human cerebral cortex, but not in the white matter of the brain stem.

摘要

针对小鼠、兔、豚鼠和人类全脑抗原的兔抗血清,在细胞毒性试验中与这些动物物种的胸腺、淋巴结和脾脏中的淋巴细胞发生交叉反应。小鼠胸腺细胞对抗脑血清最为敏感(细胞毒性指数为63%至100%);来自小鼠其他淋巴器官的细胞以及兔、豚鼠和人类的淋巴细胞则更具抗性。骨髓淋巴细胞不受这些血清中的任何一种的损伤。诱导血清细胞毒性特性的抗原仅在人类大脑皮层中发现,而不在脑干白质中。

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