Lalouel J M, Morton N E, MacLean C J, Jackson J
J Med Genet. 1977 Dec;14(6):408-14. doi: 10.1136/jmg.14.6.408.
A large body of data on segregating families is used to generate specific recurrence risks conditional on sex and birth order for the best-fitting model of polygenes plus maternal effect. The method is general for diseases of complex inheritance, and lies within the competence of any serious genetic clinic. The question of whether consultees demand as much specificity should be subordinate to the question of whether counsellors are justified in providing less.
大量关于分离家族的数据被用于生成在性别和出生顺序条件下的特定复发风险，以用于多基因加母体效应的最佳拟合模型。该方法对于复杂遗传疾病具有通用性，且任何正规的遗传诊所都有能力使用。咨询者是否需要如此多的特异性这一问题，应从属于咨询师是否有理由提供更少特异性这一问题。
