阈下电位对心脏浦肯野纤维膜电流的影响。
The effect of subthreshold potentials on the membrane current in cardiac Purkinje fibres.
作者信息
McAllister R E, Noble D
出版信息
J Physiol. 1967 May;190(2):381-7. doi: 10.1113/jphysiol.1967.sp008216.
Abstract
- In sodium-containing solutions, up to 60% of the slow outward current in Purkinje fibres can be activated by depolarizations which are too small to activate the fast sodium conductance responsible for the depolarization phase of the action potential. This result reinforces the view that the slow outward current results from slow activation of the potassium conductance rather than from slow inactivation of the sodium conductance.2. These subthreshold changes in membrane conductance are probably responsible for the dependence of the action potential and pace-maker potential durations on small changes in membrane potential in the subthreshold region.
摘要
- 在含钠溶液中，浦肯野纤维中高达60%的缓慢外向电流可被去极化激活，这些去极化太小，无法激活负责动作电位去极化阶段的快速钠电导。这一结果强化了这样一种观点，即缓慢外向电流是由钾电导的缓慢激活而非钠电导的缓慢失活导致的。2. 膜电导的这些阈下变化可能是动作电位和起搏电位持续时间依赖于阈下区域膜电位微小变化的原因。
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本文引用的文献
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A modification of the Hodgkin--Huxley equations applicable to Purkinje fibre action and pace-maker potentials.一种适用于浦肯野纤维动作电位和起搏电位的霍奇金-赫胥黎方程的修正。
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