McAllister R E
Biophys J. 1968 Aug;8(8):951-64. doi: 10.1016/S0006-3495(68)86530-0.
The Hodgkin-Huxley equations, as modified by Noble for computation of Purkinje fiber action potentials, have been solved numerically for a membrane whose equivalent circuit contains a constant resistance in series with part of the capacitance. The rates of depolarization and repolarization of the computed action potential have thereby been brought into agreement with measured values. Possible explanations of the frequently observed pre-plateau notch and of fibrillatory activity arise. The effects of a time-dependent K conductance dependent on the second power of the parameter n, instead of the fourth, have also been considered.
由诺布尔修改用于计算浦肯野纤维动作电位的霍奇金 - 赫胥黎方程,已针对一个等效电路中包含与部分电容串联的恒定电阻的膜进行了数值求解。由此计算出的动作电位的去极化和复极化速率已与测量值达成一致。出现了对频繁观察到的平台前切迹和颤动活动的可能解释。还考虑了依赖于参数(n)的二次幂而非四次幂的与时间相关的钾电导的影响。