Levitan A A
Appl Microbiol. 1967 Jul;15(4):750-3. doi: 10.1128/am.15.4.750-753.1967.
Kasugamycin is an aminoglycosidic antibiotic which was initially reported as being of potential use against Pseudomonas. Our evaluation of this antibiotic does not confirm this expectation. The median minimal inhibitory concentration (MIC) of the Pseudomonas strains tested was 250 mug/ml and the bactericidal level was 500 mug/ml. Kasugamycin was found to be slightly more active in a more basic medium (Mycin Assay broth) in which the median MIC for 11 Pseudomonas strains was 125 mug/ml. Kasugamycin manifests a modest degree of serum binding. Kasugamycin did not have any appreciable effect against a variety of bacteria tested. The only exceptions were several species of gram-negative bacteria, against which more satisfactory antibiotics already exist. Further evaluation of kasugamycin for potential human use as an antipseudomonal agent does not appear warranted.
春日霉素是一种氨基糖苷类抗生素，最初报道称其对假单胞菌有潜在用途。我们对这种抗生素的评估并未证实这一预期。所测试的假单胞菌菌株的中位最小抑菌浓度（MIC）为250微克/毫升，杀菌水平为500微克/毫升。发现春日霉素在碱性更强的培养基（迈氏测定肉汤）中活性略高，其中11株假单胞菌菌株的中位MIC为125微克/毫升。春日霉素表现出一定程度的血清结合。春日霉素对所测试的多种细菌没有任何明显作用。唯一的例外是几种革兰氏阴性菌，针对这些细菌已有更令人满意的抗生素。似乎没有必要进一步评估春日霉素作为抗假单胞菌药物用于人类的潜力。
