Cruthers L R, Szanto J, Linkenheimer W H, Maplesden D C, Brown W E
Poult Sci. 1978 Sep;57(5):1227-33. doi: 10.3382/ps.0571227.
Lonomycin (TM-481, SQ 12,525) at various concentrations in the feed was tested in controlled battery experiments against laboratory strains of single and mixed Eimeria species infections. The experimental results indicated that lonomycin at doses of .003125, .00625, or .0125% demonstrated a high degree of anticoccidial activity by preventing or reducing mortality, reducing fecal dropping scores, and allowing for normal or near-normal weight gains against single and mixed infections of 5 major pathogenic species, E. acervulina, E. brunetti, E. maxima, E. necatrix, and E. tenella. Lonomycin, at these same dosages, was highly effective against a recent field isolate obtained from a flock previously fed monensin. These studies involving 7 trials totaling 1,680 broiler chicks, have demonstrated that lonomycin at levels of .003125 to .0125% (dependent on species of Eimeria) in the feed is an effective aid in the control of avian coccidiosis in broiler chickens.
在对照分组实验中，对饲料中添加不同浓度洛尼霉素（TM - 481、SQ 12,525）的情况进行了测试，以观察其对实验室培养的单一和混合艾美耳球虫属感染菌株的作用。实验结果表明，剂量为0.003125%、0.00625%或0.0125%的洛尼霉素通过预防或降低死亡率、降低粪便评分以及使感染5种主要致病球虫（堆型艾美耳球虫、布氏艾美耳球虫、巨型艾美耳球虫、毒害艾美耳球虫和柔嫩艾美耳球虫）单一或混合感染的鸡只体重正常增加或接近正常增加，从而展现出高度的抗球虫活性。相同剂量的洛尼霉素对最近从一个此前投喂莫能菌素的鸡群中分离出的野外菌株也非常有效。这些涉及7次试验、共计1680只肉鸡的研究表明，饲料中添加0.003125%至0.0125%（取决于艾美耳球虫种类）的洛尼霉素有助于有效控制肉鸡的禽球虫病。
