Black W D
Poult Sci. 1977 Sep;56(5):1430-4. doi: 10.3382/ps.0561430.
Oxytetracycline HCL was administered to 24 hr. old and 1 week old chicks at a dosage of 5 mg./kg. The routes of administration were oral and intramuscular and in addition the week old chicks received the drug subcutaneously. The birds were killed in groups of 5, representing each of the routes of administration of the experiment, at the following intervals, 1 hr., 2 hr., 4 hr., 6 hr. and 24 hr. after administration. Oral administration of oxytetracycline results in very low levels of drugs in the tissues of both age groups, but the levels appeared lower and absorption less complete in the 1 week old birds. Intramuscular and subcutaneous administration resulted in higher levels in all the tissues of the birds in both age groups. Kidney and liver samples contained the highest tissue levels of oxytetracycline in all experiments, whereas lung and serum levels were in all cases very low and at some intervals entirely absent.
给24小时龄和1周龄的雏鸡口服盐酸土霉素，剂量为5毫克/千克。给药途径为口服和肌肉注射，此外，1周龄的雏鸡还接受皮下给药。在给药后的1小时、2小时、4小时、6小时和24小时，以每组5只的方式处死雏鸡，每组代表实验中的一种给药途径。口服土霉素后，两个年龄组雏鸡组织中的药物水平都非常低，但1周龄雏鸡体内的药物水平似乎更低，吸收也更不完全。肌肉注射和皮下注射在两个年龄组雏鸡的所有组织中都产生了较高的药物水平。在所有实验中，肾脏和肝脏样本中土霉素的组织水平最高，而肺和血清中的药物水平在所有情况下都非常低，在某些时间段甚至完全检测不到。
