El Masri S H, Lewin M R, Clark C G
Scand J Gastroenterol. 1977;12(8):999-1002. doi: 10.3109/00365527709181364.
Using an in vitro system, the effect of gastrin on the colonic handling of water and electrolytes has been investigated. Gastrin converted the normal mucosal absorption of water and sodium into a net secretion. The colonic response to gastrin was done-related with respect to sodium, and the effects were greater when it was added to the serosal side. The potassium handling of the isolated colonic mucosa was not altered by gastrin. At a concentration of 800pg/ml, gastrin signficantly reduced the normal movement of sodium from mucosa to serosa (absorption) but significantly increased serosal to mucosal movement (secretion). This alteration in the bidirectional flux of ions under the influence of gastrin may be clinically important and could account in partt for the diarrhoea associated with the Zollinger-Ellison syndrome.
利用体外系统，研究了胃泌素对结肠水和电解质处理的影响。胃泌素将水和钠的正常黏膜吸收转变为净分泌。结肠对胃泌素的反应在钠方面呈剂量相关，且当添加到浆膜侧时作用更强。胃泌素未改变离体结肠黏膜对钾的处理。在浓度为800皮克/毫升时，胃泌素显著降低了钠从黏膜到浆膜的正常移动（吸收），但显著增加了从浆膜到黏膜的移动（分泌）。在胃泌素影响下离子双向通量的这种改变可能具有临床重要性，并且可能部分解释了与佐林格-埃利森综合征相关的腹泻。
