Dollinger H C, Raptis S, Rommel K, Pfeiffer E F
Res Exp Med (Berl). 1982;180(3):223-8. doi: 10.1007/BF01852294.
The effects of synthetic human gastric I (SHG I) and gastrin-like pentapeptide (PG) on jejunal water, electrolyte, and glucose absorption were studied in 11 normal subjects. The i.v. administration of graded doses of SHG I increased plasma gastrin levels similar to those after food intake and in the Zollinger-Ellison syndrome. SHG I and PG caused no significant changes in the net movement of water and solute. The findings indicate that gastrin has no direct effect on intestinal absorption in normal man, and does not account for the mechanism of diarrhea in the Zollinger-Ellison syndrome.
在11名正常受试者中研究了合成人胃泌素I（SHG I）和胃泌素样五肽（PG）对空肠水、电解质和葡萄糖吸收的影响。静脉注射不同剂量的SHG I可使血浆胃泌素水平升高，类似于进食后以及佐林格-埃利森综合征患者的情况。SHG I和PG对水和溶质的净移动没有显著影响。这些发现表明，胃泌素对正常人的肠道吸收没有直接作用，也不能解释佐林格-埃利森综合征腹泻的机制。
