Majima S, Fukushima M, Fujita Y, Ouchi T
Tohoku J Exp Med. 1977 Dec;123(4):381-8. doi: 10.1620/tjem.123.381.
This study was undertaken to determine the effect of ulcer induced by iodoacetamide on the development of gastric carcinoma by N-methyl-N'-nitro-N-nitrosoguanidine in male Wistar rats. Fifty-six of the 62 ulcers induced by IAM were located in the fundic gland area along the limiting ridge. The incidence of fundic carcinoma was 16% in the groups treated with IAM and MNNG, while no fundic carcinoma was found in the group treated with MNNG alone. This difference was statistically significant. All the carcinomas in the fundic gland area were confined within the ulcer itself or its scar tissue, produced by IAM. These findings indicate that if an ulcer is present, carcinoma develops even in the fundic mucosa which is, if intact, resistant to the carcinogenic stimulation of MNNG. It was concluded that gastric ulcer predisposes the development of gastric carcinoma.
本研究旨在确定碘乙酰胺诱导的溃疡对雄性Wistar大鼠经N-甲基-N'-硝基-N-亚硝基胍诱发胃癌的影响。碘乙酰胺诱导的62处溃疡中有56处位于沿界限嵴的胃底腺区。接受碘乙酰胺和N-甲基-N'-硝基-N-亚硝基胍治疗的组中胃底癌的发生率为16%，而仅接受N-甲基-N'-硝基-N-亚硝基胍治疗的组中未发现胃底癌。这种差异具有统计学意义。胃底腺区的所有癌症均局限于溃疡本身或由碘乙酰胺产生的瘢痕组织内。这些发现表明，如果存在溃疡，即使是完整时对N-甲基-N'-硝基-N-亚硝基胍致癌刺激有抵抗力的胃底黏膜也会发生癌变。得出的结论是胃溃疡易引发胃癌。
