N-甲基-N'-硝基-N-亚硝基胍促进巴豆油对大鼠胃癌发生的作用。
Promoting action of croton oil on gastrocarcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
作者信息
Matsukura N, Kawachi T, Sano T, Sasajima K, Sugimura T
出版信息
J Cancer Res Clin Oncol. 1979 Apr 12;93(3):323-7. doi: 10.1007/BF00964588.
The promoting effect of croton oil on gastrocarcinogenesis by MNNG was examined in male Wistar rats. Gastric carcinomas were found in five of 10 rats given 83 micrograms/ml MNNG for three months and then 0.02% croton oil with 0.5% Tween 60 as solvent for nine months. No gastric carcinomas were found in rats given MNNG for three months and then Tween 60 only for nine months. The incidence of gastric carcinomas in these two groups was significantly different (p less than 0.05). No tumors were found in rats given only croton oil with Tween 60.
在雄性Wistar大鼠中检测了巴豆油对N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱发胃癌的促进作用。给10只大鼠喂饲83微克/毫升的MNNG三个月，然后以0.5%吐温60为溶剂喂饲0.02%巴豆油九个月，其中5只大鼠发生了胃癌。给大鼠喂饲MNNG三个月，然后仅喂饲吐温60九个月，未发现胃癌。这两组的胃癌发生率有显著差异（p<0.05）。仅给吐温60溶媒中的巴豆油的大鼠未发现肿瘤。
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