Saito T, Sasaki O, Iwamatsu M, Tamada R, Inokuchi K
J Cancer Res Clin Oncol. 1980;97(1):51-62. doi: 10.1007/BF00411278.
Serial studies by endoscopy and biopsy were made in a Beagle dog during and after oral administration of N-methyl-N'-nitro-N-nitroguanidine (MNNG). Between the 23rd and the 45th week of observation erosions and ulcers appeared at the angulus of the stomach and turned into ulcer scar. A depression with atypical glands was seen in the ulcer scar of the posterior wall of the angulus at the 94th week. It developed elevated margins at the 102nd week, when a well differentiated adenocarcinoma was found histopathologically. Ulceration and reepithelialization were observed in the early carcinoma. The carcinoma progressed into a larger one of Borrmann's type 2 at the 115th week and further into its type 3 at the 181st week. A second carcinoma with signet ring cell carcinoma developed in the anterior wall of the angulus. The two carcinomas fused and formed a single lesion. At autopsy in the 216th week the carcinoma invaded the serosa, and metastasis to regional lymph nodes was observed.
在一只比格犬口服N-甲基-N'-硝基-N-亚硝基胍（MNNG）期间及之后，通过内镜检查和活检进行了系列研究。在观察的第23周和第45周之间，胃角出现糜烂和溃疡，并转变为溃疡瘢痕。在第94周时，胃角后壁的溃疡瘢痕中可见一个有非典型腺体的凹陷。在第102周时其边缘隆起，此时组织病理学检查发现为高分化腺癌。在早期癌中观察到溃疡形成和上皮再形成。在第115周时，癌进展为较大的Borrmann 2型，在第181周时进一步发展为3型。胃角前壁出现了伴有印戒细胞癌的第二种癌。两种癌融合形成单个病变。在第216周尸检时，癌侵犯浆膜，并观察到区域淋巴结转移。
