Weigle W O
Immunology. 1967 Sep;13(3):241-8.
Thyroiditis and antibody to native thyroglobulin developed in rabbits given two series of injections of an aqueous preparation of homologous thyroglobulin, coupled to the diazonium derivatives of arsanilic and sulphanilic acids. The production of both thyroid lesions and antibody were inhibited when native homologous thyroglobulin was injected either prior to, or simultaneously with, the injections of the arsanil—sulphanil-thyroglobulin. The autoimmune response induced following injections of arsanil—sulphanil-thyroglobulin was re-stimulated by a single injection of native thyroglobulin given at a later time; however, multiple injections failed to re-stimulate and the lesions disappeared. The ability to produce autoimmune thyroiditis by injections of aqueous preparations of arsanil—sulphanil-thyroglobulin appeared to be highly dependent on the injection schedule and/or the injection dose.
给兔子注射与对氨基苯胂酸和对氨基苯磺酸重氮衍生物偶联的同源甲状腺球蛋白水性制剂的两个系列后，出现了甲状腺炎和抗天然甲状腺球蛋白抗体。当在注射对氨基苯胂酸-对氨基苯磺酸-甲状腺球蛋白之前或同时注射天然同源甲状腺球蛋白时，甲状腺病变和抗体的产生均受到抑制。在注射对氨基苯胂酸-对氨基苯磺酸-甲状腺球蛋白后诱导的自身免疫反应，在稍后时间通过单次注射天然甲状腺球蛋白而再次受到刺激；然而，多次注射未能再次刺激，病变消失。通过注射对氨基苯胂酸-对氨基苯磺酸-甲状腺球蛋白水性制剂产生自身免疫性甲状腺炎的能力似乎高度依赖于注射方案和/或注射剂量。
