甲状腺蛋白研究。IV。人甲状腺蛋白分子片段的血凝活性。
Studies on thyroid proteins. IV. Haemagglutinating activity of molecular fragments of human thyroid proteins.
作者信息
Mates G P, Shulman S
出版信息
Immunology. 1968 Jan;14(1):89-98.
Tanned cell haemagglutination experiments have shown that some fragments formed from human thyroglobulin after completed trypsin hydrolysis are able to react with a human thyroiditis auto-antiserum. These same fragments had been unable to affect the precipitation reactions of the same antiserum. These results have indicated that in this immune system at least, the antigenic sites prominent in the precipitation reaction are not those most prominent in haemagglutination. It indicates also that evaluation of the immunological activity of the autoimmune serum on the single basis of its precipitation reaction may be misleading.
鞣酸细胞血凝试验表明，人甲状腺球蛋白经胰蛋白酶完全水解后形成的一些片段能够与人甲状腺炎自身抗血清发生反应。而这些相同的片段此前无法影响该抗血清的沉淀反应。这些结果表明，至少在这个免疫系统中，沉淀反应中突出的抗原位点并非血凝反应中最突出的那些。这也表明仅基于沉淀反应来评估自身免疫血清的免疫活性可能会产生误导。
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