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甲状腺蛋白研究。IV。人甲状腺蛋白分子片段的血凝活性。

Studies on thyroid proteins. IV. Haemagglutinating activity of molecular fragments of human thyroid proteins.

作者信息

Mates G P, Shulman S

出版信息

Immunology. 1968 Jan;14(1):89-98.

PMID:5635757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409251/
Abstract

Tanned cell haemagglutination experiments have shown that some fragments formed from human thyroglobulin after completed trypsin hydrolysis are able to react with a human thyroiditis auto-antiserum. These same fragments had been unable to affect the precipitation reactions of the same antiserum. These results have indicated that in this immune system at least, the antigenic sites prominent in the precipitation reaction are not those most prominent in haemagglutination. It indicates also that evaluation of the immunological activity of the autoimmune serum on the single basis of its precipitation reaction may be misleading.

摘要

鞣酸细胞血凝试验表明，人甲状腺球蛋白经胰蛋白酶完全水解后形成的一些片段能够与人甲状腺炎自身抗血清发生反应。而这些相同的片段此前无法影响该抗血清的沉淀反应。这些结果表明，至少在这个免疫系统中，沉淀反应中突出的抗原位点并非血凝反应中最突出的那些。这也表明仅基于沉淀反应来评估自身免疫血清的免疫活性可能会产生误导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3be/1409251/87bee67016ba/immunology00396-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3be/1409251/87bee67016ba/immunology00396-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3be/1409251/87bee67016ba/immunology00396-0106-a.jpg

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引用本文的文献

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Splitting of human thyroglobulin. I. Reduction and alkylation.人甲状腺球蛋白的裂解。I. 还原与烷基化
Clin Exp Immunol. 1969 Jul;5(1):129-40.
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Clin Exp Immunol. 1969 Sep;5(3):285-97.
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本文引用的文献

1
STUDIES ON ORGAN SPECIFICITY. XV. IMMUNOHISTOLOGIC EVALUATION OF REACTIONS PRODUCED BY THYROID AUTOANTIBODIES.器官特异性研究。第十五部分。甲状腺自身抗体产生反应的免疫组织学评估。
J Immunol. 1963 Aug;91:204-9.
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The properties of thyroglobulin. I. The effects of alkali.甲状腺球蛋白的特性。I. 碱的作用。
J Biol Chem. 1960 May;235:1326-34.
3
Fluorescent antibody studies in human thyroiditis: auto-antibodies to an antigen of the thyroid colloid distinct from thyroglobulin.人类甲状腺炎的荧光抗体研究：针对不同于甲状腺球蛋白的甲状腺胶体抗原的自身抗体。
Clin Exp Immunol. 1974 Jun;17(2):267-79.
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Isolation and properties of a succinylated subunit of human thyroglobulin.人甲状腺球蛋白琥珀酰化亚基的分离与特性
Clin Exp Immunol. 1978 Mar;31(3):341-50.
5
Splitting of human thyroglobulin. IV. The antigenicity of the pepsin-derived fragments.人甲状腺球蛋白的裂解。IV. 胃蛋白酶衍生片段的抗原性。
Clin Exp Immunol. 1977 Feb;27(2):245-53.
Br J Exp Pathol. 1961 Aug;42(4):307-16.
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The nature of the thyroid auto-antibodies present in patients with Hashimoto's thyroiditis (lymphadenoid goitre).桥本甲状腺炎（淋巴性甲状腺肿）患者体内存在的甲状腺自身抗体的性质。
Biochem J. 1958 Jun;69(2):248-56. doi: 10.1042/bj0690248.
5
The isolation and properties of a fragment of bovine-serum albumin which retains the ability to combine with rabbit antiserum.一种保留与兔抗血清结合能力的牛血清白蛋白片段的分离及其特性
Biochem J. 1957 Aug;66(4):677-86. doi: 10.1042/bj0660677.
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Studies on organ specificity. IV. Production of rabbit thyroid antibodies in the rabbit.器官特异性研究。IV. 家兔体内兔甲状腺抗体的产生
J Immunol. 1956 Jun;76(6):408-16.
7
Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.蛋白质和抗体研究的微量方法。I. 用鞣酸和蛋白质处理的红细胞进行血凝和血凝抑制反应的程序及一般应用。
J Immunol. 1954 May;72(5):360-7.
8
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9
Cytotoxicity of human thyroid autoantibodies.
Ann N Y Acad Sci. 1965 Jun 30;124(2):626-43. doi: 10.1111/j.1749-6632.1965.tb18991.x.