Dunlop W, Hill L M, Landon M J, Oxley A, Jones P
Lancet. 1978 Aug 12;2(8085):346-9. doi: 10.1016/s0140-6736(78)92944-6.
Changes in coagulation tests (fibrin/fibrinogen degradation products, factor-VIII activity, and platelet-count) and in renal function (creatinine clearance and serum concentration, clearance, and fractional reabsorption of urate) were measured in late pregnancy. 10 patients with severe preeclampsia showed changes in both coagulation and renal function when compared with 13 normotensive controls. 18 patients with mild pre-eclampsia had changes in renal function only. Results from 5 patients with essential hypertension did not differ from those of the normotensive group. When results from the patients with severe pre-eclampsia were arranged in order of decreasing protein excretion, only renal-function tests correlated significantly with this ranking. It is suggested that, in the management of patients with established preeclampsia, assessment of renal function may be of greater practical value than measurement of the degree of coagulopathy.
在妊娠晚期对凝血试验（纤维蛋白/纤维蛋白原降解产物、因子 VIII 活性和血小板计数）以及肾功能（肌酐清除率、血清浓度、尿酸清除率和尿酸分数重吸收）的变化进行了测量。与 13 名血压正常的对照组相比，10 名重度子痫前期患者的凝血和肾功能均出现了变化。18 名轻度子痫前期患者仅肾功能出现了变化。5 名原发性高血压患者的结果与血压正常组无差异。当按蛋白尿排泄量递减顺序排列重度子痫前期患者的结果时，只有肾功能检查与该排名显著相关。提示在已确诊子痫前期患者的管理中，评估肾功能可能比测量凝血病变程度具有更大的实用价值。
