Auerbach C
Science. 1967 Dec 1;158(3805):1141-7. doi: 10.1126/science.158.3805.1141.
Since the discovery of the first potent mutagens over 20 years ago, progress in mutation research has been rapid. Many new mutagens, belonging to a variety of chemical classes, have been discovered, and for some of them the reaction with DNA in vitro has been established. It seems that the findings of these chemical investigations usually also apply to viruses which are treated outside the cell. This has made chemical mutagens into an important tool for the analysis of the genetic code. When DNA is treated inside the cell, its reactions would not be expected to be always identical with those observed in vitro; in one case they have, indeed, been found to be different.
自20多年前发现首批强效诱变剂以来，突变研究进展迅速。人们发现了许多属于各种化学类别的新诱变剂，其中一些诱变剂与DNA在体外的反应已得到确定。这些化学研究结果似乎通常也适用于在细胞外处理的病毒。这使得化学诱变剂成为分析遗传密码的重要工具。当在细胞内处理DNA时，预计其反应并不总是与体外观察到的反应相同；事实上，在一个案例中已发现它们有所不同。
