Horie A, Yasumoto K, Ueda H, Watanabe Y, Kotoo Y, Kurita Y
Acta Pathol Jpn. 1977 Nov;27(6):907-15.
A clear of clear cell adenocarcinoma of the uterus combined with early invasive squamous cell carcinoma of the cervix was reported. The adenocarcinoma was found to be in histologic continuity with the squamous cell carcinoma as well as with the cervical glandular epithelium. Ultrastructurally, the epithelial cells of the adenocarcinoma showed junctional complexes, well developed microvilli, parallel stacks of granular endoplasmic reticulums and twisted rope-like nucleoli, all of which were in accord with the cytologic characteristics of endometrial carcinoma. Hormonal study of the tumor suggested the presence of estrogen receptor and a lack of endocrine productibility. These findings provide an additional support for the Müllerian duct origin of uterine clear cell adenocarcinoma.
报道了一例子宫透明细胞腺癌合并宫颈早期浸润性鳞状细胞癌。发现腺癌与鳞状细胞癌以及宫颈腺上皮存在组织学连续性。超微结构上，腺癌的上皮细胞显示连接复合体、发育良好的微绒毛、平行排列的颗粒状内质网和扭曲的绳状核仁，所有这些都符合子宫内膜癌的细胞学特征。对该肿瘤的激素研究表明存在雌激素受体且缺乏内分泌产生能力。这些发现为子宫透明细胞腺癌的苗勒管起源提供了额外支持。
