Serezhin B S, Lomakina I I, Skripnik S V, Smirnov O A, Zhigulina G A
Vopr Onkol. 1985;31(3):40-7.
Widely varying numbers of endocrine cells were identified in 12 out of 64 cases of uterine cancer in the course of histochemical and electron microscopic examination. Some neoplasms had morphologic features of apudoma of various degree of differentiation, the remaining ones (adenocarcinoma and adenosquamous carcinoma) were identified as tumors of endocrine origin if their cells contained certain specific metabolites most reliably detectable by the argyrophilic method after Grimelius and electron microscopy. The results of the study and literature data suggest that both endocrine and epithelial cells originate from multipotential epithelial stem cells.
在64例子宫癌病例中的12例，经组织化学和电子显微镜检查发现内分泌细胞数量差异很大。一些肿瘤具有不同分化程度的APUD瘤的形态学特征，其余的（腺癌和腺鳞癌）如果其细胞含有某些特定代谢产物，在采用Grimelius嗜银法及电子显微镜检查后最可靠地检测到，则被确定为内分泌起源的肿瘤。研究结果和文献数据表明，内分泌细胞和上皮细胞均起源于多能上皮干细胞。
