Barnard A C, Duck I M, Lynn M S, Timlake W P
Biophys J. 1967 Sep;7(5):463-91. doi: 10.1016/S0006-3495(67)86599-8.
In an earlier paper exact integral equations were derived for the surface potentials resulting from sources within an irregularly shaped inhomogeneous body. These exact equations cannot usually be solved. In this paper a discrete analogue is constructed which is not straightforward to solve, but which can be treated by careful mathematical methods. In particular a deflation procedure greatly facilitates the iterative solution of the problem and overcomes the divergence encountered by other authors. Numerical solutions obtained for simple geometries are compared to the exact analytic solutions available in such cases. The necessary convergence of the solutions of the discrete analog towards the solution of the continuous problem is shown to occur only if the coefficients of the discrete analogue are carefully evaluated. Calculations are then presented for realistic thoracic geometries, typical results being presented as surface potential maps. Finally the important effect of the internal regional inhomogeneities, particularly a realistic cardiac blood mass, is demonstrated by obtaining vector loops with and without these effects.
在一篇早期论文中,推导出了关于不规则形状非均匀体内源所产生的表面电势的精确积分方程。这些精确方程通常无法求解。本文构建了一个离散模拟方程,它虽不易求解,但可通过精细的数学方法来处理。特别是一种降阶程序极大地促进了该问题的迭代求解,并克服了其他作者所遇到的发散问题。针对简单几何形状获得的数值解与此类情况下可用的精确解析解进行了比较。结果表明,仅当仔细评估离散模拟方程的系数时,离散模拟方程的解才会朝着连续问题的解收敛。然后给出了针对实际胸部几何形状的计算结果,典型结果以表面电势图的形式呈现。最后,通过获取有和没有这些影响的向量环,证明了内部区域不均匀性,特别是实际心脏血团的重要影响。