溶酶体与膜循环利用。一种假说。
Lysosomes and membrane recycling. A hypothesis.
作者信息
Dean R T
出版信息
Biochem J. 1977 Dec 15;168(3):603-5. doi: 10.1042/bj1680603.
Abstract
A mechanism for intralysosomal membrane recycling is proposed. After invagination of the lysosomal membrane during autophagy, intralysosomal vesicles are formed. It is suggested that membrane can bleb out from these internal vesicles, probably in the form of very small vesicles, and return to the external lysosomal membrane by membrane fusion. This mechanism would conserve lysosomal membrane during autophay, and is analogous to current models of plasma-membrane recycling. Its relationship to turnover of lysosomal-membrane proteins and other proteins is discussed.
摘要
提出了一种溶酶体内膜循环的机制。在自噬过程中溶酶体膜内陷后，形成溶酶体内小泡。有人认为，膜可能从这些内部小泡中膨出，很可能是以非常小的小泡形式，然后通过膜融合回到溶酶体的外部膜。这种机制将在自噬过程中保存溶酶体膜，并且类似于目前的质膜循环模型。文中还讨论了它与溶酶体膜蛋白和其他蛋白周转的关系。
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本文引用的文献
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