Heyburn P J, Peacock M
Clin Endocrinol (Oxf). 1977 Dec;7 Suppl:209s-214s. doi: 10.1111/j.1365-2265.1977.tb03383.x.
A retrospective study of the comparative effects of vitamin D, dihydrotachysterol and 1alpha-hydroxyvitamin D3 was undertaken in twenty-eight patients with hypoparathyroidism. The vitamin D compounds restored plasma calcium to the normal range in most patients with comparable actions on the gut, bone and kidney. Although the vitamin D compounds had a direct action on kidney and bone in the absence of PTH, the major action in maintaining plasma calcium was on the gut. Plasma phosphate fell due to a reduction in renal tubular reabsorption. Dihydrotachysterol and 1alpha-hydroxyvitamin D3 had significant practical advantages over vitamin D in their rapid onset of action and their relatively short biological half-life.
对28例甲状旁腺功能减退患者进行了一项关于维生素D、二氢速甾醇和1α-羟基维生素D3比较效果的回顾性研究。这些维生素D化合物在大多数患者中使血浆钙恢复到正常范围，对肠道、骨骼和肾脏有类似作用。尽管在没有甲状旁腺激素（PTH）的情况下，这些维生素D化合物对肾脏和骨骼有直接作用，但维持血浆钙的主要作用是在肠道。由于肾小管重吸收减少，血浆磷酸盐下降。二氢速甾醇和1α-羟基维生素D3在起效迅速和生物半衰期相对较短方面比维生素D具有显著的实际优势。
