人类补体成分激活C3b反馈循环。II. 使用替代途径的成分。
The activation of the C3b feedback cycle with human complement components. II. Using components of the alternative pathway.
作者信息
Mak L W, Majewski J, Lachmann P J
出版信息
Clin Exp Immunol. 1977 Nov;30(2):211-21.
Abstract
The C3 convertase of the C3b feedback cycle was generated in the fluid phase from C3b and factors B and D. It was shown to be an effective decomplementing agent when reacted with human serum. Many of the effects observed were dependent on the operation of the feedback during the ongoing reaction. Oxidization of factor B with iodine did not significantly increase the potency or the stability of the enzyme. Treatment of C3b with antrypol inhibited the formation of the enzyme. In preliminary experiments in the rat, the convertase was successfully formed in vivo, accompanied by cleavage of C3, consumption of C5, C6 and C7, and a biphasic change in the circulating neutrophils.
摘要
C3b 反馈循环的 C3 转化酶在液相中由 C3b 与因子 B 和 D 生成。当与人类血清反应时，它被证明是一种有效的补体灭活剂。观察到的许多效应取决于正在进行的反应过程中反馈的运作。用碘氧化因子 B 不会显著提高该酶的效力或稳定性。用抗胰蛋白酶处理 C3b 会抑制该酶的形成。在大鼠的初步实验中，该转化酶在体内成功形成，同时伴有 C3 的裂解、C5、C6 和 C7 的消耗以及循环中性粒细胞的双相变化。
相似文献
1
The activation of the C3b feedback cycle with human complement components. II. Using components of the alternative pathway.人类补体成分激活C3b反馈循环。II. 使用替代途径的成分。
Clin Exp Immunol. 1977 Nov;30(2):211-21.
2
The activation of the C3b feedback cycle with human complement components. I. Through the classical pathway.人补体成分C3b反馈循环的激活。I. 通过经典途径。
Clin Exp Immunol. 1977 Nov;30(2):200-10.
3
Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.血浆蛋白C4结合蛋白和C3b灭活剂对经典途径C3转化酶的调节作用。
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6596-600. doi: 10.1073/pnas.76.12.6596.
4
Residual hemolytic and proteolytic activity expressed by Bb after decay-dissociation of C3b,Bb.C3b、Bb衰变解离后Bb所表达的残余溶血和蛋白水解活性。
J Immunol. 1984 Mar;132(3):1425-9.
5
Increased enzymatic activity of the alternative pathway convertase when bound to the erythrocytes of paroxysmal nocturnal hemoglobinuria.当与阵发性夜间血红蛋白尿症的红细胞结合时，替代途径转化酶的酶活性增加。
J Clin Invest. 1982 Feb;69(2):337-46. doi: 10.1172/jci110457.
6
A circulating inhibitor of fluid-phase amplification. C3 convertase formation in systemic lupus erythematosus.液相放大的循环抑制剂。系统性红斑狼疮中C3转化酶的形成。
J Clin Invest. 1985 Jun;75(6):1786-95. doi: 10.1172/JCI111891.
7
Regulation of the C3 nephritic factor stabilized C3/C5 convertase of complement by purified human erythrocyte C3b receptor.纯化的人红细胞C3b受体对补体C3肾炎因子稳定的C3/C5转化酶的调节作用。
Clin Exp Immunol. 1982 Oct;50(1):209-14.
8
Trypanosoma lewisi: restriction of alternative complement pathway C3/C5 convertase activity.路氏锥虫：替代补体途径C3/C5转化酶活性的限制
Exp Parasitol. 1987 Jun;63(3):260-71. doi: 10.1016/0014-4894(87)90172-x.
9
Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.替代补体途径初始C3转化酶的形成。通过天然C3中假定硫酯的自发水解获得C3b样活性。
J Exp Med. 1981 Sep 1;154(3):856-67. doi: 10.1084/jem.154.3.856.
10
Modulation of the formation of the human amplification C3 convertase of complement by polycations.聚阳离子对人补体扩增C3转化酶形成的调节作用。
Immunology. 1983 Sep;50(1):27-33.
引用本文的文献
1
The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B. Purification and N-terminal amino acid sequence of a peptide from C2a containing a free thiol group.碘和硫醇封闭试剂与人补体成分C2和B因子的反应。来自C2a的含游离硫醇基团肽段的纯化及N端氨基酸序列
Biochem J. 1983 Jul 1;213(1):201-9. doi: 10.1042/bj2130201.
本文引用的文献
1
Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides.通过卤化氰将肽和蛋白质与多糖进行化学偶联。
Nature. 1967 Jun 24;214(5095):1302-4. doi: 10.1038/2141302a0.
2
Two anticomplementary factors in cobra venom: hemolysis of guinea pig erythrocytes by one of them.眼镜蛇毒中的两种抗补体因子：其中一种可使豚鼠红细胞发生溶血。
J Immunol. 1969 Nov;103(5):944-52.
3
Enharncement of the hemolytic activity of the second component of human complement by oxidation.通过氧化增强人补体第二成分的溶血活性。
J Exp Med. 1967 Dec 1;126(6):1013-25. doi: 10.1084/jem.126.6.1013.
4
The alternate pathway of complement activation. The role of C3 and its inactivator (KAF).补体激活的替代途径。C3及其灭活剂（KAF）的作用。
Immunology. 1973 Feb;24(2):259-75.
5
C3 proactivator convertase and its mode of action.C3 前活化剂转化酶及其作用方式。
J Exp Med. 1972 Apr 1;135(4):1003-8. doi: 10.1084/jem.135.4.1003.
6
Modulation of C3b hemolytic activity by a plasma protein distinct from C3b inactivator.一种不同于C3b灭活剂的血浆蛋白对C3b溶血活性的调节作用。
Science. 1976 Sep 10;193(4257):1011-3. doi: 10.1126/science.948757.
7
Haemolytic diffusion plate assays for factors B and D of the alternative pathway of complement activation.补体激活替代途径中B因子和D因子的溶血扩散平板试验。
Immunochemistry. 1976 Apr;13(4):317-24. doi: 10.1016/0019-2791(76)90341-4.
8
The activation of the C3b feedback cycle with human complement components. I. Through the classical pathway.人补体成分C3b反馈循环的激活。I. 通过经典途径。
Clin Exp Immunol. 1977 Nov;30(2):200-10.
Zotero 插件