小鼠对异种红细胞的免疫反应。II. 对与绵羊或小鼠在分类学上相关物种的红细胞的抗体形成。
The immune response to heterologous red cells in mice. II. Antibody formation to red cells from species taxonomically related to sheep or mouse.
作者信息
Dietrich F M, Dukor P
出版信息
Immunology. 1967 Dec;13(6):585-95.
An attempt was made to establish the relative immunogenicity of various heterologous erythrocytes in the mouse. The immune response to multispecies red cells was examined by zone centrifugation of the antibodies, and by studying cross-reactivity between the varioys erythrocytes, time-course of haemagglutinin formation, and finally, antigen dose—antibody response relationships. As compared to sheep erythrocytes, goat erythrocytes were found to have a greatly reduced agglutinability, which merely simulated a reduced immunogenicity. However, erythrocytes from gerbil and hamster proved to be genuinely weaker antigens in the mouse. For alkylating agents, anti-metabolites and anti-mitotic compounds the drug-sensitivity of the immune response to cells of different antigenicity was not altered.
尝试在小鼠中确定各种异种红细胞的相对免疫原性。通过抗体的区带离心、研究各种红细胞之间的交叉反应性、血凝素形成的时间进程以及最终的抗原剂量-抗体反应关系，来检测对多种物种红细胞的免疫反应。与绵羊红细胞相比，发现山羊红细胞的凝集性大大降低，这仅仅模拟了免疫原性的降低。然而，沙鼠和仓鼠的红细胞在小鼠中被证明是真正较弱的抗原。对于烷化剂、抗代谢物和抗有丝分裂化合物，对不同抗原性细胞的免疫反应的药物敏感性没有改变。
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