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2月龄新西兰黑小鼠对绵羊红细胞的7S抗体反应增强。

Increased 7S antibody response to sheep erythrocytes in the 2-month-old NZB mouse.

作者信息

Baum J

出版信息

Clin Exp Immunol. 1969 Sep;5(3):251-63.

PMID:5810150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1579108/
Abstract

The validity of the use of the NZB mouse as a model for systemic lupus erythematosus is supported by a study of the 7S and 19S antibody response to immunization with sheep erythrocytes. In comparison with CBA and C3H mice the 2-month-old NZB animals made significantly more whole serum antibody. DBA, C57BL and A/Jax animals made about the same amount of whole serum antibody. Compared to all the control groups the NZB animals made significantly more 7S antibody in eight of twenty examinations of 2-mercaptoethanol resistant antibody studied from 1 to 8 weeks after immunization. Old NZB animals showed the same degree of 7S antibody production as the 2-month-old animals and were no different from a group of old White Swiss mice. The NZB animals thus show early immunological hyperreactivity most prominently in the 7S immunoglobulin fraction at a time when virtually no autoantibodies are present.

摘要

一项关于用绵羊红细胞免疫后7S和19S抗体反应的研究支持了将NZB小鼠用作系统性红斑狼疮模型的有效性。与CBA和C3H小鼠相比，2月龄的NZB动物产生的全血清抗体明显更多。DBA、C57BL和A/Jax动物产生的全血清抗体量大致相同。在免疫后1至8周对2-巯基乙醇抗性抗体进行的20次检测中，有8次显示，与所有对照组相比，NZB动物产生的7S抗体明显更多。老年NZB动物产生7S抗体的程度与2月龄动物相同，与一组老年瑞士白化小鼠没有差异。因此，NZB动物在几乎不存在自身抗体的时候，就已在7S免疫球蛋白部分最显著地表现出早期免疫反应亢进。

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Increased 7S antibody response to sheep erythrocytes in the 2-month-old NZB mouse.2月龄新西兰黑小鼠对绵羊红细胞的7S抗体反应增强。
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本文引用的文献

1
AUTOIMMUNE DISEASE IN NZB/BL MICE. I. PATHOLOGY AND PATHOGENESIS OF A MODEL SYSTEM OF SPONTANEOUS GLOMERULONEPHRITIS.NZB/BL小鼠的自身免疫性疾病。I. 自发性肾小球肾炎模型系统的病理学与发病机制
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2
STUDIES ON MOUSE ANTIBODIES. I. THE RESPONSE TO SHEEP RED CELLS.小鼠抗体研究。I. 对绵羊红细胞的反应。
J Immunol. 1965 Jul;95:26-38.
3
ANTIBODY SYNTHESIS AT THE CELLULAR LEVEL. ANTIBODY-INDUCED SUPPRESSION OF 19S AND 7S ANTIBODY RESPONSE.细胞水平的抗体合成。抗体对19S和7S抗体反应的抑制作用。
J Exp Med. 1965 Jun 1;121(6):969-89. doi: 10.1084/jem.121.6.969.
4
THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. I. PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO SINGLE AND MULTIPLE INJECTIONS OF ANTIGEN.大鼠对绵羊红细胞产生耐受性的机制。I. 对单次和多次注射抗原的噬斑形成细胞及抗体反应。
J Exp Med. 1965 May 1;121(5):671-81. doi: 10.1084/jem.121.5.671.
5
GLOBULINS OF NZB MOUSE ERYTHROCYTES.新西兰黑鼠红细胞的球蛋白
J Immunol. 1964 Dec;93:897-901.
6
ANTINUCLEAR FACTOR IN MICE.小鼠中的抗核因子。
J Immunol. 1964 Jul;93:148-54.
7
THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS.新西兰黑鼠自身免疫性疾病的自然史。与人类自身免疫表现模式的比较。
Ann Intern Med. 1963 Sep;59:265-76. doi: 10.7326/0003-4819-59-3-265.
8
Circulating antibody and anaphylaxis in mice.小鼠体内的循环抗体与过敏反应
J Immunol. 1961 Mar;86:302-6.
9
Antibody production in inbred strains of mice.近交系小鼠的抗体产生
J Immunol. 1953 Jan;70(1):61-7.
10
A sensitive hemagglutination assay method for dinitrophenyl-specific antibodies. The effect of antibody binding affinity on titers.
J Immunol. 1967 Mar;98(3):648-52.

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