Sumaya C V, Brunell P A
J Infect Dis. 1977 Dec;136 Suppl:S597-600. doi: 10.1093/infdis/136.supplement_3.s597.
One hundred thirty-three children in San Antonio, Texas, received intramuscular injections of split-virus or whole-virus preparations of killed, monovalent influenza A/New Jersey/76 virus vaccine or placebo. Thirty-three children were in the three- to five-year-old age group, and 100 were in the six- to 11-year-old group. A minimal antibody response occurred following injection of the first dose of vaccine. A second or booster dose that was administered approximately four months after the first dose resulted in a significant antibody response, even in children who developed a minimal or no detectable immune response to the initial dose. This improved immune response was observed following administration of two doses of either split-virus or whole-virus vaccines. Reactions by the vaccine recipients on the whole were minimal. Reaction indices determined in both age groups after administration of the booster dose were usually less than those after the first dose. The high prevalence, 78% overall, of antibodies to influenza A/Victoria/75 virus demonstrated that this virus was previously prevalent in our area.
得克萨斯州圣安东尼奥市的133名儿童接受了肌肉注射，注射的是裂解病毒或全病毒制剂的甲型流感病毒/新泽西/76灭活单价疫苗或安慰剂。33名儿童在3至5岁年龄组，100名儿童在6至11岁组。注射第一剂疫苗后出现了最小程度的抗体反应。在第一剂疫苗大约四个月后接种的第二剂或加强剂导致了显著的抗体反应，即使是那些对初始剂量产生最小或未检测到免疫反应的儿童也是如此。在接种两剂裂解病毒或全病毒疫苗后都观察到了这种改善的免疫反应。总体而言，疫苗接种者的反应很小。在两个年龄组中，加强剂量接种后测定的反应指数通常低于第一剂接种后。对甲型流感病毒/维多利亚/75病毒抗体的高流行率（总体为78%）表明该病毒此前在我们地区流行。
