Modlin J F, Smith D H, Harding L
J Infect Dis. 1977 Dec;136 Suppl:S626-31. doi: 10.1093/infdis/136.supplement_3.s626.
Various doses of two whole-virus and one split-product bivalent influenza A/New Jersey/76-A/Victoria/75 vaccines were administered to 253 children aged six to 18 years. There were no statistically significant differences in either reactivity or humoral antibody response among the 167 children in seven chronic disease categories and 86 healthy children. The whole-virus vaccines were associated with unacceptably high rates of reaction when given in sufficiently antigenic initial doses but were relatively nonreactive when used for booster immunization. Split-product vaccines were no more reactive than placebo. All vaccine preparations induced adequate seroconversion rates and protective titers of antibody to A/Victoria virus after one dose and to A/New Jersey virus after two doses.
将两种全病毒和一种裂解产物的二价甲型流感疫苗（新泽西/76 - A/维多利亚/75）的不同剂量接种给253名6至18岁的儿童。7类慢性病患儿中的167名以及86名健康儿童在反应性或体液抗体反应方面均无统计学上的显著差异。当给予足够抗原性的初始剂量时，全病毒疫苗会出现高得令人难以接受的反应率，但用于加强免疫时反应相对较小。裂解产物疫苗的反应性并不比安慰剂高。所有疫苗制剂在接种一剂后对A/维多利亚病毒、两剂后对A/新泽西病毒均诱导出足够的血清转化率和保护性抗体滴度。
