Hall C B, Modlin J F, Hilman B C, Boyer K M, Cherry J D, Lauer B A, Lerman S J, McIntosh K, Gross P A, Baucum R
J Infect Dis. 1977 Dec;136 Suppl:S632-7. doi: 10.1093/infdis/136.supplement_3.s632.
During the recent nationwide trials of influenza vaccine, 121 children with cardiac disease, aged three to 18 years, were evaluated with respect to their immune response and reaction rate after administration of a whole-virus or split-virus bivalent influenza A/New Jersey/76-A/Victoria/75 vaccine given as a single dose or two divided doses. The serologic response of the cardiac children did not differ significantly from that of the total group of high-risk children or normal children who recived the same vaccine. The major reaction to the vaccines was fever, which occurred in one-fourth to one-half of children receiving the whole-virus vaccines. The split-virus vaccines were generally well tolerated. The reaction index of the cardiac children was slightly lower than that of the normal children receiving the same vaccine during the single-dose trial but higher during the two-dose trial. The second dose was generally better tolerated than the first dose. Reactions in the children with cardiac disease could not be adequately evaluated according to specific diagnoses or functional disabilities.
在近期全国范围内的流感疫苗试验中，对121名年龄在3至18岁的心脏病患儿进行了评估，观察他们在接种单剂量或两剂分开接种的全病毒或裂解病毒二价甲型流感/新泽西/76-甲型流感/维多利亚/75疫苗后的免疫反应和反应率。心脏病患儿的血清学反应与接受相同疫苗的高危儿童或正常儿童总体的血清学反应没有显著差异。疫苗的主要反应是发热，接受全病毒疫苗的儿童中有四分之一至二分之一出现发热。裂解病毒疫苗通常耐受性良好。在单剂量试验中，心脏病患儿的反应指数略低于接受相同疫苗的正常儿童，但在两剂试验中则较高。第二剂通常比第一剂耐受性更好。无法根据具体诊断或功能障碍对心脏病患儿的反应进行充分评估。
