皮质醇对体外培养的正常及类风湿性滑膜成纤维细胞合成糖胺聚糖的影响。
Effects of cortisol on glycosaminoglycans synthesized by normal and rheumatoid synovial fibroblasts in vitro.
作者信息
Saarni H, Tammi M, Vuorio E
出版信息
Scand J Rheumatol. 1977;6(4):222-4. doi: 10.3109/03009747709095454.
PMID:607389
Abstract
Cultivated rheumatoid synovial fibroblasts synthesize hyaluronic acid which has a changed molecular weight distribution in Sepharose 2B gel chromatography, when compared with normal synovial fibroblasts. Cortisol has no effect on the molecular weight distribution of either normal or rheumatoid hyaluronate. However, it does reduce the hyaluronic acid synthesis, by more than 50% in both cell types at low, near physiological plasma concentrations of the steroid.
摘要
与正常滑膜成纤维细胞相比，培养的类风湿性滑膜成纤维细胞合成的透明质酸在琼脂糖2B凝胶色谱中的分子量分布发生了变化。皮质醇对正常或类风湿性透明质酸的分子量分布均无影响。然而，在接近生理血浆浓度的低剂量类固醇作用下，它确实会使两种细胞类型中的透明质酸合成减少50%以上。
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