类风湿关节炎中的金化合物。一次研讨会报告。

Gold compounds in rheumatoid arthritis. Report of a symposium.

作者信息

Gottlieb N L, Bjelle A

出版信息

Scand J Rheumatol. 1977;6(4):225-30. doi: 10.3109/03009747709095455.

Abstract

A vast accumulation of clinical experience and controlled studies justifies the use of gold compounds in selected cases of rheumatoid arthritis. The striking therapeutical efficacy observed in some patients has stimulated active research to clarify the pharmacokinetics and mechanisms of action of gold compounds. Based on this knowledge, the possibility of selecting gold-responsive patients may be enhanced, and the frequency of adverse reactions decreased. Liberal indications and inexperience in administration and control have given gold therapy mixed reputation. A symposium in Umeå, Sweden, summarized present knowledge and current concepts among Scandinavian rheumatologists on the rational use of gold compounds.

摘要

大量的临床经验和对照研究证明，在某些类风湿关节炎病例中使用金化合物是合理的。在一些患者中观察到的显著治疗效果激发了积极的研究，以阐明金化合物的药代动力学和作用机制。基于这些知识，选择对金化合物有反应的患者的可能性可能会提高，不良反应的发生率也会降低。宽泛的适应症以及在给药和控制方面缺乏经验，使金疗法的声誉褒贬不一。瑞典于默奥召开的一次研讨会总结了斯堪的纳维亚风湿病学家关于合理使用金化合物的现有知识和当前观念。