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1
Role of purine N-3 in the biologic activities of poly(A) and poly(I).嘌呤N-3在聚腺苷酸（poly(A)）和聚肌苷酸（poly(I)）生物活性中的作用。
Nucleic Acids Res. 1976 Jun;3(6):1591-601. doi: 10.1093/nar/3.6.1591.
2
Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid).聚（2-氮杂腺苷酸）和聚（2-氮杂肌苷酸）的生物活性。
Nucleic Acids Res. 1977 Oct;4(10):3643-53. doi: 10.1093/nar/4.10.3643.
3
Dependence of interferon induction on nucleic acid conformation.干扰素诱导对核酸构象的依赖性。
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3788-92. doi: 10.1073/pnas.73.11.3788.
4
2'-Fluoropolynucleotide-directed reverse transcriptase reactions. Effect of homologous polynucleotides.2'-氟多聚核苷酸指导的逆转录酶反应。同源多聚核苷酸的作用。
J Enzyme Inhib. 1995;8(4):261-5. doi: 10.3109/14756369509020133.
5
Effects of Poly(1-vinyluracil) and Poly(9-vinyladenine) on viral RNA-directed DNA polymerase.聚（1-乙烯基尿嘧啶）和聚（9-乙烯基腺嘌呤）对病毒RNA指导的DNA聚合酶的影响。
Cancer Res. 1976 Apr;36(4):1273-7.
6
Poly(2-methylthio-7-deazainosinic acid)--hydrophobic stabilization of polynucleotide secondary structure by the 2-methylthio group.聚（2-甲硫基-7-脱氮肌苷酸）——2-甲硫基对多核苷酸二级结构的疏水稳定作用
Nucleic Acids Res. 1983 Sep 10;11(17):6107-20. doi: 10.1093/nar/11.17.6107.
7
Polynucleotide displacement reactions: detection by interferon induction.多核苷酸置换反应：通过干扰素诱导进行检测
Biochemistry. 1976 Feb 24;15(4):717-24. doi: 10.1021/bi00649a001.
8
Inhibition of oncornavirus functions by 2'-azido polynucleotides.2'-叠氮多核苷酸对致癌病毒功能的抑制作用。
Proc Natl Acad Sci U S A. 1975 Jan;72(1):284-8. doi: 10.1073/pnas.72.1.284.
9
The effect of bisulfite modification on the template activity of DNA for DNA polymerase I.亚硫酸氢盐修饰对DNA聚合酶I模板活性的影响。
Nucleic Acids Res. 1974 Jul;1(7):889-99. doi: 10.1093/nar/1.7.889.
10
A potent interferon inducer derived from poly (7-deazainosinic acid).一种源自聚（7-脱氮肌苷酸）的强效干扰素诱导剂。
Biochemistry. 1974 Oct 8;13(21):4400-8. doi: 10.1021/bi00718a025.

引用本文的文献

1
Inhibition of murine leukaemia virus reverse transcriptase by 2-halogenated polyadenylic acids.2-卤代聚腺苷酸对鼠白血病病毒逆转录酶的抑制作用。
Biochem J. 1982 Jun 1;203(3):755-60. doi: 10.1042/bj2030755.
2
Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid).聚（2-氮杂腺苷酸）和聚（2-氮杂肌苷酸）的生物活性。
Nucleic Acids Res. 1977 Oct;4(10):3643-53. doi: 10.1093/nar/4.10.3643.

本文引用的文献

1
Polynucleotides. XXII. Synthesis and properties of poly 7-deazainosinic acid.多核苷酸。XXII。聚7-脱氮肌苷酸的合成与性质
Nucleic Acids Res. 1974 Jan;1(1):53-61. doi: 10.1093/nar/1.1.53.
2
Some physical properties of poly 7-deazaadenylic acid (poly Tubercidin phosphoric acid).聚7-脱氮腺苷酸（聚杀结核菌素磷酸）的一些物理性质。
J Mol Biol. 1968 Dec;38(3):437-41. doi: 10.1016/0022-2836(68)90399-9.
3
Polynucleotides. XXI. Synthesis and properties of poly 1-deazaadenylic acid and poly 3-deazaadenylic acid.多核苷酸。XXI。聚1-脱氮腺苷酸和聚3-脱氮腺苷酸的合成与性质
J Biochem. 1974 Jul;76(1):107-15. doi: 10.1093/oxfordjournals.jbchem.a130534.
4
A potent interferon inducer derived from poly (7-deazainosinic acid).一种源自聚（7-脱氮肌苷酸）的强效干扰素诱导剂。
Biochemistry. 1974 Oct 8;13(21):4400-8. doi: 10.1021/bi00718a025.
5
Interferon induction by synthetic polynucleotides: importance of purine N-7 and strandwise rearrangement.合成多核苷酸诱导干扰素：嘌呤N-7和链间重排的重要性
Proc Natl Acad Sci U S A. 1974 Jan;71(1):182-6. doi: 10.1073/pnas.71.1.182.
6
Inhibition of RNA directed DNA polymerase of murine leukemia virus by 2'-O-alkylated polyadenylic acids.2'-O-烷基化聚腺苷酸对鼠白血病病毒RNA指导的DNA聚合酶的抑制作用。
Biochem Biophys Res Commun. 1974 Jul 24;59(2):608-15. doi: 10.1016/s0006-291x(74)80023-9.
7
A more sensitive assay system for the detection of RNA-dependent DNA polymerase in oncogenic RNA viruses.
Biochim Biophys Acta. 1973 Dec 21;331(3):328-32. doi: 10.1016/0005-2787(73)90018-x.
8
Anti-complement activity of polynucleotides.
Biochem Biophys Res Commun. 1975 Nov 3;67(1):255-63. doi: 10.1016/0006-291x(75)90310-1.
9
Biological, biochemical, and physicochemical evidence for the existence of the polyadenylic-polyuridylic-polyinosinic acid triplex.聚腺苷酸-聚尿苷酸-聚肌苷酸三链体存在的生物学、生物化学及物理化学证据。
J Biol Chem. 1975 Apr 10;250(7):2521-31.
10
Failure of duplexes based on polylaurusin (poly(L), "Polyformycin B") to induce interferon.
Biochem Biophys Res Commun. 1975 Feb 3;62(3):658-64. doi: 10.1016/0006-291x(75)90449-0.

嘌呤N-3在聚腺苷酸（poly(A)）和聚肌苷酸（poly(I)）生物活性中的作用。

Role of purine N-3 in the biologic activities of poly(A) and poly(I).

作者信息

de Clercq E, Torrence P F, Fukui T, Ikehara M

出版信息

Nucleic Acids Res. 1976 Jun;3(6):1591-601. doi: 10.1093/nar/3.6.1591.

DOI:10.1093/nar/3.6.1591
PMID:60741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC343016/
Abstract

Poly(c3A) (poly 3-deazaadenylic acid) and poly(c3I) (poly 3-deazainosinic acid) differ in biological reactivity from their parent compounds poly(A) and poly(I) and from their 7-deaza counterparts poly(c7A) and poly(c7I). Three parameters of biological reactivity were evaluated : (1 degree) interferon induction, (2 degrees) anti-complement activity, (3 degrees) reverse transcriptase inhibition. Unlike poly(A)-poly(U), poly(I)-poly(C) and poly(I)-poly(br5C), the mixtures of poly(c3A) + POLY(U), poly(c3I) + poly(C), and poly(c3I) + poly(br5C) failed to elicit an interferon response in "super-induced" primary rabbit kidney cells; Poly(I) and its analogs poly(c3I) and poly(c7I) inhibited hemolytic complement activity, whereas poly(A) and its analogs poly(c3A) and poly(c7A) failed to do so. Both poly(I) and poly(c7I), but not poly(c3I), lost their anti-complement potency when annealed to either poly(C) or poly(A)-poly(U). Similarly, poly(I) and poly(c7I), but not poly(c3I), suppressed the interferon inducing ability of poly(A)-poly(U), suggesting that both poly(I) and poly(c7I), but not poly(c3I), added to poly(A)-poly(U) to form a triple-helical structure. Poly(I), poly(C7I) and poly(c7A)exerted a distinct inhibitory effect on turine leukemia virus, while under the same conditions poly(c3I) and poly(c3A) showed little, if any, inhibitory effect.

摘要

聚（c3A）（聚3 - 脱氮腺苷酸）和聚（c3I）（聚3 - 脱氮肌苷酸）在生物学活性上与其母体化合物聚（A）和聚（I）以及它们的7 - 脱氮类似物聚（c7A）和聚（c7I）不同。评估了生物学活性的三个参数：（1）干扰素诱导，（2）抗补体活性，（3）逆转录酶抑制。与聚（A）-聚（U）、聚（I）-聚（C）和聚（I）-聚（br5C）不同，聚（c3A）+聚（U）、聚（c3I）+聚（C）以及聚（c3I）+聚（br5C）的混合物在“超诱导”的原代兔肾细胞中未能引发干扰素反应；聚（I）及其类似物聚（c3I）和聚（c7I）抑制溶血补体活性，而聚（A）及其类似物聚（c3A）和聚（c7A）则无此作用。当与聚（C）或聚（A）-聚（U）退火时，聚（I）和聚（c7I）（而非聚（c3I））失去其抗补体效力。同样，聚（I）和聚（c7I）（而非聚（c3I））抑制聚（A）-聚（U）的干扰素诱导能力，这表明聚（I）和聚（c7I）（而非聚（c3I））添加到聚（A）-聚（U）中形成了三螺旋结构。聚（I）、聚（C7I）和聚（c7A）对鼠白血病病毒有明显的抑制作用，而在相同条件下聚（c3I）和聚（c3A）几乎没有抑制作用（如果有抑制作用的话也很小）。