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感染小鼠肺中类支原体灰色肺和大鼠肺炎病原体的精细结构与定位

Fine structure and location of the mycoplasma-like gray lung and rat pneumonia agents in infected mouse lung.

作者信息

Gay F W

出版信息

J Bacteriol. 1967 Dec;94(6):2048-61. doi: 10.1128/jb.94.6.2048-2061.1967.

DOI:10.1128/jb.94.6.2048-2061.1967
PMID:6074407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC276939/
Abstract

The mycoplasma-like gray lung and rat pneumonia agents were indistinguishable in fine structure and location in infected mouse lung. Both agents resembled mycoplasmas in fine structure, being bounded by a 110 A unit membrane which enclosed an internal region of 20 to 30 A branching fibrils and groups of 120 A ribosomes. They differed from mycoplasmas in having an 80 to 90 A electron-lucent space separating the unit membrane from the internal material, and the internal region was bounded by a 30 to 40 A unbranched fibril. In division, the organisms appeared to form a transverse trilayered "division plate." In overall shape, the organisms seemed to be thick circular or oval plates, and they tended to lie in palisade arrangement on cell surfaces. Both agents were free in large numbers in the alveoli and respiratory bronchioles, and on the surface of intro-alveolar mononuclear cells, but were not seemingly associated with lung cells as such. Intracellular organisms were within membrane-bounded inclusions.

摘要

类支原体的灰色肺病原体和大鼠肺炎病原体在感染小鼠肺中的精细结构和位置上难以区分。两种病原体在精细结构上都类似于支原体，由一层110埃的单位膜包裹，内部区域包含20至30埃的分支原纤维和120埃的核糖体群。它们与支原体的不同之处在于，单位膜与内部物质之间有一个80至90埃的电子透明空间，内部区域由30至40埃的无分支原纤维界定。在分裂时，这些生物体似乎形成了一个横向的三层“分裂板”。从整体形状来看，这些生物体似乎是厚圆形或椭圆形的板，它们倾向于在细胞表面呈栅栏状排列。两种病原体在肺泡和呼吸性细支气管中大量游离，也存在于肺泡内单核细胞表面，但似乎与肺细胞本身并无关联。细胞内的生物体存在于膜包裹的内含物中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/dbf8e989da37/jbacter00407-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/7c736c557e9f/jbacter00407-0274-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/97200beb89f1/jbacter00407-0278-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/d5002fe90b15/jbacter00407-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/25a00b3c973e/jbacter00407-0280-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/293e029bc1da/jbacter00407-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/bbb45d0bb983/jbacter00407-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/dbf8e989da37/jbacter00407-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/7c736c557e9f/jbacter00407-0274-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/650b846955ca/jbacter00407-0275-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/5e0ffa37a51f/jbacter00407-0276-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/d2161f2a2a83/jbacter00407-0277-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/97200beb89f1/jbacter00407-0278-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/d5002fe90b15/jbacter00407-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/25a00b3c973e/jbacter00407-0280-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/88d39e253f94/jbacter00407-0281-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/293e029bc1da/jbacter00407-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/bbb45d0bb983/jbacter00407-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/276939/dbf8e989da37/jbacter00407-0284-a.jpg

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本文引用的文献

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Ultrastructure of Mycoplasma hominis.人型支原体的超微结构
J Bacteriol. 1965 Jul;90(1):180-92. doi: 10.1128/jb.90.1.180-192.1965.
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Chemotherapeutic experiments with grey lung virus.用灰肺病毒进行的化疗实验。
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大鼠慢性肺炎的病因及小鼠实验性疾病的研究
Infect Immun. 1972 Jul;6(1):83-91. doi: 10.1128/iai.6.1.83-91.1972.
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Respiratory disease in a colony of rats. II. Isolation of Mycoplasma pulmonis from the natural disease, and the experimental disease induced with a cloned culture of this organism.一群大鼠中的呼吸道疾病。II. 从自然疾病以及用该生物体的克隆培养物诱发的实验性疾病中分离出肺支原体。
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