Gay F W, Maguire M E, Baskerville A
Infect Immun. 1972 Jul;6(1):83-91. doi: 10.1128/iai.6.1.83-91.1972.
The lungs of conventional rats with chronic pneumonia contained Streptobacillus moniliformis and Mycoplasma pulmonis. These organisms singly and in combination failed to produce lung disease when inoculated into specific pathogen-free rats. On the other hand, diseased lung homogenate not containing cultivable organisms caused a chronic pneumonia when inoculated into specific pathogen-free rats. The organism involved was seen by electron microscopy and is morphologically indistinguishable from the grey lung agent of Andrewes and Glover and Nelson's enzootic bronchiectasis "virus." All of these agents have morphological and biological properties which indicate close relationship to the mycoplasmas. However, we failed to culture them either in tissue cultures or on inanimate media and conclude that a group of highly fastidious mycoplasma-like agents are a cause of chronic pneumonia in rodents.
患有慢性肺炎的普通大鼠的肺中含有念珠状链杆菌和肺支原体。将这些微生物单独或混合接种到无特定病原体的大鼠体内时，均未能引发肺部疾病。另一方面，不含可培养微生物的患病肺匀浆接种到无特定病原体的大鼠体内时，会引发慢性肺炎。通过电子显微镜观察到了所涉及的微生物，其形态与安德鲁斯和格洛弗的灰色肺病原体以及尼尔森的地方性支气管扩张“病毒”无法区分。所有这些病原体都具有形态学和生物学特性，表明它们与支原体密切相关。然而，我们未能在组织培养或无生命培养基中培养出它们，并得出结论，一组高度挑剔的支原体样病原体是啮齿动物慢性肺炎的病因。
