Rasey J S, Nelson N J
Acta Radiol Ther Phys Biol. 1977 Dec;16(6):525-8. doi: 10.3109/02841867709133974.
Mice were whole-body-irradiated with 5 fractions of roentgen rays in 5 days, 5 fractions of cyclotron neutrons in 5 days, or with mixed neutron-photon fractionated radiation, in the sequence n-n-x-x-x or n-x-x-x-n. The LD50/4 day values were determined. Roentgen rays and neutrons interact in the additive manner in the mixed fractionation schemes: effective dose per fraction is as predicted from the roentgen ray-only and neutron-only experiments. This essentially agrees with HENDRY et coll. (1976). However, no trend was found towards a less-than -additive effect which was observed by those authors and has also been suggested in skin response to mixed schemes (NELSON et coll. 1975).
小鼠在5天内接受5次伦琴射线全身照射、在5天内接受5次回旋加速器中子照射，或接受中子-光子分次混合照射，照射顺序为n-n-x-x-x或n-x-x-x-n。测定了LD50/4天的值。在混合分次照射方案中，伦琴射线和中子以相加方式相互作用：每次分次的有效剂量如仅用伦琴射线和仅用中子的实验所预测。这与亨德里等人（1976年）的研究基本一致。然而，未发现有小于相加效应的趋势，而那些作者曾观察到这种效应，并且在皮肤对混合照射方案的反应中也有人提出过这种效应（纳尔逊等人，1975年）。
