Shabad L M, Janisheva N J, Firtz W
Arch Geschwulstforsch. 1980;50(8):705-14.
Polycyclic aromatic hydrocarbons (PAK) are tightly connected with the history of chemical carcinogenesis since they are carcinogenic components of carbon blacks, tars, paraffines, and mineral oils. In selected examples it is shown for some cases of professional cancer that they can induce cancer in man. The carcinogenic effect obtained with PAK containing extracts of very different products, correlates also in animal tests with the detected contents of PAK and particularly of benzo[a]-pyrene (BaP). This concerns, among others, tars, carbon blacks, exhaust gases of combustion engines, and environmental pollutions. BaP may be regarded as representative for the PAKs. PAKs and BaP are ubiquitous. The sources of contamination are briefly summarized. Epidemiologic studies show also a connection between human cancer and influence of PAK. In the opinion of the authors and for the given reasons the PAKs are carcinogenic for many to a very high degree of security.
多环芳烃（PAK）与化学致癌作用的历史紧密相连，因为它们是炭黑、焦油、石蜡和矿物油中的致癌成分。在某些职业性癌症案例中表明，它们可在人类中诱发癌症。用含有PAK的不同产品提取物所获得的致癌效应，在动物试验中也与检测到的PAK含量，特别是苯并[a]芘（BaP）的含量相关。这尤其涉及焦油、炭黑、内燃机废气和环境污染。BaP可被视为PAK的代表。PAK和BaP无处不在。简要总结了污染来源。流行病学研究也表明人类癌症与PAK的影响之间存在关联。根据作者的观点及给定原因，PAK对许多人具有高度安全性的致癌性。
