Shorokhova V B
Radiobiologiia. 1984 Nov-Dec;24(6):831-4.
It was shown that after a single administration of tritium oxide in a dose of 22.2 MBq/g body mass the liver mass increased, the concentration of nucleic acids decreased and the biosynthesis rate increased during a one-month observation. By the end of the observation period (the first year) the parameters under study were normalized. The long-term administration of tritium oxide in daily doses of 0.37, 0.925 and 1.85 MBq/g body mass caused changes in the nucleic acid metabolism which were less manifest (at early times), than in the case of a single injection. At the same time, the long-term administration of tritium oxide in the dose of 0.925 MBq/g caused a substantial disturbance of the nucleic acid metabolism at later times (after 2-9 months).
结果表明，以22.2MBq/g体重的剂量单次给予氧化氚后，在为期一个月的观察期内，肝脏重量增加，核酸浓度降低，生物合成速率提高。到观察期结束（第一年）时，所研究的参数恢复正常。以0.37、0.925和1.85MBq/g体重的日剂量长期给予氧化氚会引起核酸代谢变化，与单次注射相比，这些变化在早期不太明显。同时，以0.925MBq/g的剂量长期给予氧化氚在后期（2 - 9个月后）会导致核酸代谢的严重紊乱。
