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实验性诱导骨髓发育不全后实验大鼠脾脏粒细胞生成形态学

Splenic granulopoietic morphology in laboratory rats after experimental induction of marrow hypoplasia.

作者信息

Berger J

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(5):604-9.

PMID:6083934
Abstract

Within the granulopoietic recovery phase the proportion of neutrophils and their precursors in the spleen was elevated from 1.7 +/- 0.3% (controls) to 14.7 +/- 2.2% (on day 14 after cyclophosphamide). Splenic granulopoiesis persisted for a time after the appearance of marrow recovery. These data suggest that the rat adult spleen can become a markedly granulopoietic organ during the regeneration of granulopoiesis which follows experimentally induced myelosuppression.

摘要

在粒细胞生成恢复阶段，脾脏中嗜中性粒细胞及其前体细胞的比例从1.7±0.3%（对照组）升高至14.7±2.2%（环磷酰胺注射后第14天）。骨髓恢复出现后，脾脏粒细胞生成持续了一段时间。这些数据表明，在实验性诱导骨髓抑制后的粒细胞生成再生过程中，成年大鼠脾脏可成为一个显著的粒细胞生成器官。

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