Babu U M, Lai C H, Maurer P H
J Immunogenet. 1984 Jun-Aug;11(3-4):251-4. doi: 10.1111/j.1744-313x.1984.tb01061.x.
All mice responding to the terpolymer GLA40 make GL, GA and GLA specific antibodies irrespective of their response to GL or GA alone. The mice displayed positive T cell proliferative responses against the homologous terpolymer, but no T cell responses were obtained with GL, which is non-immunogenic in mice. T cells from GLA immune mice, which are also responders to GA, such as mice of H-2 haplotypes a, b, d, k and r, could be stimulated by GA. T cells from GLA immune mice of H-2 haplotypes p and q which are non-responders to GA could not be stimulated by GA. On the other hand, T cells from H-2s mice immune to GLA and which are also responders to GA alone could not be stimulated by GA. Thus mice of H-2 haplotypes p, q and s recognize the terpolymer via 'GLA' determinants alone, whereas mice of H-2 haplotypes a, b, d, k and r may recognize both GA and GLA determinants in GLA terpolymer.
所有对三元共聚物GLA40有反应的小鼠，无论其对单独的GL或GA的反应如何，都会产生GL、GA和GLA特异性抗体。这些小鼠对同源三元共聚物表现出阳性T细胞增殖反应，但对在小鼠中无免疫原性的GL未获得T细胞反应。来自对GA也有反应的GLA免疫小鼠的T细胞，如H-2单倍型a、b、d、k和r的小鼠，可被GA刺激。来自H-2单倍型p和q的GLA免疫小鼠（对GA无反应） 的T细胞不能被GA刺激。另一方面，来自对GLA免疫且对单独的GA也有反应的H-2s小鼠的T细胞不能被GA刺激。因此，H-2单倍型p、q和s的小鼠仅通过“GLA”决定簇识别三元共聚物，而H-2单倍型a、b、d、k和r的小鼠可能识别GLA三元共聚物中的GA和GLA决定簇。
