Lai C H, Babu U M, Maurer P H
J Immunogenet. 1984 Oct-Dec;11(5-6):355-63. doi: 10.1111/j.1744-313x.1984.tb00821.x.
The T cell proliferative responses to GLA terpolymers among mice of H-2 a, b, d, k, q, r and s haplotypes are heterogeneous. Following immunization with GLA20, GLA40 and GLA60, mouse T cells reacted well with the three terpolymers. The cross-reactions of the above T cells to GLA5 decreased as the alanine content in the terpolymers (immunogens) increased, whereas the trend of the cross-reactions to GA40 did not change. The RIII strain showed no cross-reaction with GLA5. Only mice of H-2 haplotypes q and s failed to show cross-reactions to GA40. Mice of the H-2q haplotype are genetic non-responders to GA40, whereas those of the H-2s haplotype are responders. Immunization of SJL mice with GA40 mixed with GLA40 led to reduction of the specific T cell response to GA40. This reduction of GA40 specific T cell responses in SJL mice by GLA40 occurred during the early stage of the immune response. The kinetic study showed that it was necessary to inject the GLA40 intraperitoneally at least 7 days before GA40 in order for the reduction to take place. The PETLES and lymph node T cells from DBA/1 mice were found to respond to GLA40 differently, and these cells from SJL mice responded differently to GA40.
在具有H-2 a、b、d、k、q、r和s单倍型的小鼠中，T细胞对GLA三元共聚物的增殖反应是异质性的。用GLA20、GLA40和GLA60免疫后，小鼠T细胞对这三种三元共聚物反应良好。随着三元共聚物（免疫原）中丙氨酸含量的增加，上述T细胞对GLA5的交叉反应降低，而对GA40的交叉反应趋势没有变化。RIII品系与GLA5没有交叉反应。只有H-2单倍型q和s的小鼠对GA40没有交叉反应。H-2q单倍型的小鼠是对GA40的遗传无反应者，而H-2s单倍型的小鼠是反应者。用GA40与GLA40混合免疫SJL小鼠导致对GA40的特异性T细胞反应降低。GLA40导致SJL小鼠中GA40特异性T细胞反应的这种降低发生在免疫反应的早期阶段。动力学研究表明，为了发生这种降低，必须在GA40之前至少7天腹腔注射GLA40。发现来自DBA/1小鼠的PETLES和淋巴结T细胞对GLA40的反应不同，而来自SJL小鼠的这些细胞对GA40的反应也不同。
