Walker M, Litherland H K, Murphy J, Smith J A
J Hosp Infect. 1984 Dec;5 Suppl A:101-6. doi: 10.1016/0195-6701(84)90039-2.
An unacceptably high infection rate in patients undergoing vascular surgery prompted two studies on these patients. The first study confirmed the problem and described antibiotic usage which was not standardized. A second double blind randomized study compared antibiotic usage in two groups of patients, receiving vein grafts or synthetic grafts. Patients receiving vein grafts were randomized either to placebo or cefazolin 2 g 1 h pre-operatively and every 6 h for 48 h. Patients receiving synthetic grafts were randomized either to cefazolin 1 g or to cefazolin 2 g 1 h pre-operatively and every 6 h for 48 h. Four of 50 vein graft patients developed a purulent discharge. Two of these infected patients received placebo and two received the cefazolin 2 g protocol. Of 90 patients receiving a synthetic graft, four became infected. Three patients were randomized to the cefazolin 1 g protocol and one to the cefazolin 2 g protocol. No statistically significant differences were observed.
血管手术患者中出现的高得令人无法接受的感染率促使针对这些患者开展了两项研究。第一项研究证实了该问题，并描述了抗生素使用不规范的情况。第二项双盲随机研究比较了两组接受静脉移植物或合成移植物的患者的抗生素使用情况。接受静脉移植物的患者被随机分为两组，一组术前1小时接受安慰剂，另一组术前1小时接受2克头孢唑林，术后每6小时一次，共48小时。接受合成移植物的患者被随机分为两组，一组术前1小时接受1克头孢唑林，另一组术前1小时接受2克头孢唑林，术后每6小时一次，共48小时。50名接受静脉移植物的患者中有4人出现脓性分泌物。其中2名感染患者接受了安慰剂，2名接受了2克头孢唑林方案。在90名接受合成移植物的患者中，有4人感染。3名患者被随机分配到1克头孢唑林方案组，1名患者被随机分配到2克头孢唑林方案组。未观察到统计学上的显著差异。
