Blokha V V, Iamnikova S S, Karpovich L G, Iakhno M A, Zakstel'skaia L Ia
Vopr Virusol. 1984 Nov-Dec;29(6):672-5.
Heterogeneity of antibodies against influenza virus hemagglutinin has been confirmed. Various subpopulations of antibodies to the A/Khabarovsk/15/76 hemagglutinin were demonstrated some of which showed greater affinity to MRC-11 hemagglutinin than to the HA of the strain inducing this antibody synthesis. Apparently subpopulations of antibodies with low affinity to their "own" epitopes in the hemagglutinin-immunogen may develop which, however, may show a sufficiently high affinity to these epitopes in hemagglutinins of other strains.
针对流感病毒血凝素的抗体异质性已得到证实。已证明针对A/哈巴罗夫斯克/15/76血凝素的各种抗体亚群，其中一些对MRC-11血凝素的亲和力高于对诱导该抗体合成的毒株的血凝素的亲和力。显然，可能会产生对血凝素免疫原中其“自身”表位亲和力低的抗体亚群，然而，这些亚群对其他毒株血凝素中的这些表位可能显示出足够高的亲和力。
