Castro J E, Sadler T E, Jones P D
Dev Biol Stand. 1977;38:277-81.
The effects of Corynebacterium parvum (C. parvum) on Lewis lung tumour metastases have been studied. I.v. and i.p., but not s.c. C. parvum significantly reduced pulmonary metastases. When combined with excision of the primary tumour, C. parvum given not more than 2 days before caused slight reduction of metastases, but when given earlier, it caused significant reduction and some mice were cured. Metastases were increased by silica or cortisone acetate but were unaffected by trypan blue. The antimetastatic action of C. parvum was not altered by these treatments. Thymectomy and irradiation did not affect tumour metastases, or the antimetastatic action of C. parvum, whereas ALS depressed metastasis and abrogated the protective effects of C. parvum. It appears that the inhibitory effects of C. parvum on tumour metastases are mediated through macrophages in concert with a subpopulation of T2 lymphocytes.
已对短小棒状杆菌（C. parvum）对Lewis肺癌转移的影响进行了研究。静脉注射和腹腔注射（而非皮下注射）短小棒状杆菌可显著减少肺转移。当与原发肿瘤切除相结合时，在原发肿瘤切除前不超过2天给予短小棒状杆菌会使转移略有减少，但如果更早给予，则会使转移显著减少，且一些小鼠得以治愈。二氧化硅或醋酸可的松会增加转移，但锥虫蓝对转移无影响。这些处理并未改变短小棒状杆菌的抗转移作用。胸腺切除和照射不影响肿瘤转移，也不影响短小棒状杆菌的抗转移作用，而抗淋巴细胞血清会抑制转移并消除短小棒状杆菌的保护作用。看来短小棒状杆菌对肿瘤转移的抑制作用是通过巨噬细胞与T2淋巴细胞亚群协同介导的。
