Mosley J, Sadler T E, Castro J E
Dev Biol Stand. 1977;38:285-9.
Surgical operations depress immune responses. The aim of this study was to observe the effects of operation (amputation) on the growth of the Lewis lung tumour and its metastases and to see if C. parvum counteracted them. Anaesthesia alone, or with amputation, did not affect the growth of the primary tumour but C. parvum depressed it. Anaesthesia did not affect the number of pulmonary metastases but amputation caused significant increase. C. parvum inhibited metastases and completely counteracted the effects of operation. Large amounts of cortisone significantly increased metastases but small doses did not. Experiments in adrenalectomized mice suggested the effects of operation were due to non specific stress.
外科手术会抑制免疫反应。本研究的目的是观察手术（截肢）对Lewis肺癌生长及其转移的影响，并探究微小隐孢子虫是否能对抗这些影响。单独麻醉或麻醉加截肢均不影响原发性肿瘤的生长，但微小隐孢子虫会抑制其生长。麻醉不影响肺转移灶的数量，但截肢会使其显著增加。微小隐孢子虫可抑制转移，并完全抵消手术的影响。大剂量可的松会显著增加转移灶数量，而小剂量则不会。对肾上腺切除小鼠的实验表明，手术的影响是由非特异性应激引起的。
