Basić I, Withers R H, Kastelan A, Milas L
Dev Biol Stand. 1977;38:311-6.
We have investigated whether C. parvum (CP)-induced stimulation of hematopoiesis affects the survival of mice exposed to the whole body irradiation (WBI). C3Hf/Bu mice treated with CP exhibit an increased hematopoietic colony forming activity in their spleens and blood, but not in their bone marrow, as determined by the exogenous spleen colony assay. Also, CP-treated C3Hf/Bu as well as CBA mice show an increase in their endogenous colonies. This increased hematopoietic activity caused by CP treatment did not protect mice from the consequences of the WBI ranging from 650 to 950 rads. In fact, more mice died if they had been treated with CP. A decrease in the number of erythrocytes was more pronounced in mice treated with CP and irradiation than in those given irradiation alone.
我们研究了微小隐孢子虫（CP）诱导的造血刺激是否会影响接受全身照射（WBI）小鼠的存活情况。通过外源性脾集落试验测定，用CP处理的C3Hf/Bu小鼠脾脏和血液中的造血集落形成活性增加，但其骨髓中的活性未增加。此外，用CP处理的C3Hf/Bu小鼠以及CBA小鼠的内源性集落也有所增加。CP处理引起的这种造血活性增加并不能保护小鼠免受650至950拉德全身照射的影响。事实上，接受CP处理的小鼠死亡更多。与仅接受照射的小鼠相比，接受CP处理并照射的小鼠红细胞数量减少更为明显。
