Sarfati P D, Genik P, Morisset J
Regul Pept. 1985 Jul;11(3):261-73. doi: 10.1016/0167-0115(85)90058-8.
Pancreatic hypertrophy and hyperplasia following chronic joint (CA + SE), or separate, caerulein (CA: 1 microgram . kg-1) and secretin (SE: 75 micrograms . kg-1) administration were studied in parallel with pancreatic somatostatin (SRIF) contents following 2, 4, 7 and 10 days of treatment. Parameters indicative of pancreatic growth (tissue weight, DNA and protein contents, cellular protein concentrations) increased significantly after 2 days of CA or CA + SE and reached a plateau between days 4 and 10. SE merely induced a mild hypertrophy after 4 days. Endogenous pancreatic SRIF contents varied upon treatment, differently so with each peptide regimen. Indeed, CA and CA + SE treatments decreased total SRIF contents after 2 days with no effect thereafter. SE also decreased the latter after 2 days while significant increases were observed after 7 and 10 days. The inverse relationship seemingly existing between SRIF contents and the amplitude of hormonally-induced pancreatic growth supports the hypothesis that endogenous pancreatic SRIF, operating as an 'antigrowth' factor, may participate in the exogenous CA, SE and CA + SE stimulated pancreatic growth phenomena.
在慢性联合使用蛙皮素（CA + SE）或单独使用蛙皮素（CA：1微克·千克⁻¹）和促胰液素（SE：75微克·千克⁻¹）后，对胰腺肥大和增生进行了研究，并与治疗2、4、7和10天后胰腺生长抑素（SRIF）的含量进行了平行比较。在给予CA或CA + SE 2天后，指示胰腺生长的参数（组织重量、DNA和蛋白质含量、细胞蛋白质浓度）显著增加，并在第4天至第10天之间达到平台期。SE仅在4天后诱导轻度肥大。内源性胰腺SRIF含量随治疗而变化，每种肽方案的变化不同。实际上，CA和CA + SE治疗在2天后降低了总SRIF含量，此后没有影响。SE在2天后也降低了总SRIF含量，而在7天和10天后观察到显著增加。SRIF含量与激素诱导的胰腺生长幅度之间似乎存在的反比关系支持了这样的假设，即作为“抗生长”因子起作用的内源性胰腺SRIF可能参与外源性CA、SE和CA + SE刺激的胰腺生长现象。
