Almond J W, Stanway G, Cann A J, Westrop G D, Evans D M, Ferguson M, Minor P D, Spitz M, Schild G C
Vaccine. 1984 Sep;2(3):177-84. doi: 10.1016/0264-410x(84)90081-1.
This article summarizes recent work on the determinants of antigenicity in poliovirus type 3 and reports on experiments in progress aimed at understanding the molecular basis of attenuation in Sabin's type 3 vaccines. Ways in which this new information might be used to produce alternative, safe, inexpensive, multivalent vaccines against polio and other enteroviruses are discussed.
本文总结了近期关于3型脊髓灰质炎病毒抗原性决定因素的研究工作，并报告了正在进行的旨在了解萨宾3型疫苗减毒分子基础的实验。还讨论了如何利用这些新信息来生产针对脊髓灰质炎和其他肠道病毒的替代、安全、廉价的多价疫苗。
