Björck C G, Bergqvist D, Esquivel C, Nilsson B, Rudsvik Y
Acta Chir Scand. 1984;150(8):629-33.
An experimental model based on a combination of endothelial injury and flow reduction, was used to induce jugular vein thrombosis in the rabbit. The influence of conventional heparin, a low molecular weight fragment (LMW heparin; M.W. 4 000-5 000) and a heparin analogue (sodium pentosan polysulfate) was compared. The drugs were administered intravenously during the induction of thrombosis. The control animals received Ringer's lactate. All treatments significantly reduced the frequency of thrombosis. In addition, LMW heparin caused a significant reduction of thrombus weight. Moreover, it was shown that local treatment with conventional heparin and LMW heparin after endothelial damage both reduced the frequency of thrombosis.
基于内皮损伤和血流减少相结合的实验模型，用于诱导家兔颈静脉血栓形成。比较了常规肝素、低分子量片段（低分子量肝素；分子量4000 - 5000）和肝素类似物（聚磺基戊聚糖钠）的影响。在血栓形成诱导过程中静脉内给药这些药物。对照动物接受乳酸林格液。所有治疗均显著降低了血栓形成的频率。此外，低分子量肝素使血栓重量显著降低。而且，研究表明内皮损伤后用常规肝素和低分子量肝素进行局部治疗均降低了血栓形成的频率。
