Matsumiya T, Oka T
Tokai J Exp Clin Med. 1984 Aug;9(3):223-30.
The specific opiate antagonist naloxone rapidly reverses hypotension caused by endotoxin, hypovolemia and spinal transection. The fact that naloxone appears to act as a causative level to improve shock pathophysiology, as well as its extensive clinical use for opiate overdose, makes this drug a particularly clinical use for opiate overdose, makes this drug a particularly attractive potential therapeutic agent for the treatment of shock in humans. The electrophysiological effects of naloxone were studied on c-fiber reflex in spinal and intact cats. The drugs were injected in to the right cephalic vein. Results can be summarized as follows: Naloxone in the intact cat had a more pronounced facilitating effect than in the spinal cat. Naloxone given as a one shot injection was more potentiating than naloxone given as a 5 minute injection. Naloxone antagonized the facilitation of a small dose of ketamine-HCL in the intact cat and also the depression of a large dose ketamine-HCL. Naloxone antagonized capsaicin on c-fiber reflex. This result supports that naloxone has the antagonizable inhibitory effect of substance-P. Naloxone for the first injection had an effective response but additional naloxone did not facilitate the c-fiber reflex.
特异性阿片拮抗剂纳洛酮能迅速逆转由内毒素、血容量不足和脊髓横断引起的低血压。纳洛酮似乎在改善休克病理生理学方面起到了因果作用，而且它在临床上广泛用于治疗阿片类药物过量，这使得该药物成为治疗人类休克的一种特别有吸引力的潜在治疗剂。研究了纳洛酮对脊髓完整和脊髓损伤猫的C纤维反射的电生理作用。药物经右侧头静脉注射。结果总结如下：在脊髓完整的猫中，纳洛酮的促进作用比脊髓损伤的猫更明显。一次性注射纳洛酮比5分钟注射纳洛酮的增强作用更强。纳洛酮可拮抗小剂量盐酸氯胺酮对脊髓完整猫的促进作用，也可拮抗大剂量盐酸氯胺酮的抑制作用。纳洛酮可拮抗辣椒素对C纤维反射的作用。这一结果支持纳洛酮对P物质具有可拮抗的抑制作用。首次注射纳洛酮有有效反应，但再次注射纳洛酮则不能促进C纤维反射。
