Amr S, Rosa C, Wehmann R, Birken S, Nisula B
Ann Endocrinol (Paris). 1984;45(4-5):321-6.
We have observed unusual forms of human choriogonadotropin (hCG) in the urine of patients with gestational trophoblastic neoplasia. These molecules were of two types: Carboxyterminal fragments of hCG beta-subunit and desialylated forms of hCG. Substantial amounts of these materials were found in the urines of 83% and 50%, respectively, of the patients (n = 12) studied. In contrast, negligible quantities were found in the urine of 14 healthy pregnant women. Also, these unusual forms were not detectable in normal controls given an infusion of hCG. These findings indicate that these forms have clinical potential for diagnosing gestational trophoblastic neoplasia and differentiating it from normal pregnancy.
我们在妊娠滋养细胞肿瘤患者的尿液中观察到了人绒毛膜促性腺激素（hCG）的异常形式。这些分子有两种类型：hCGβ亚基的羧基末端片段和去唾液酸化形式的hCG。在所研究的12例患者中，分别有83%和50%的患者尿液中发现了大量此类物质。相比之下，在14名健康孕妇的尿液中发现的量可忽略不计。此外，在输注hCG的正常对照者尿液中未检测到这些异常形式。这些发现表明，这些形式在诊断妊娠滋养细胞肿瘤并将其与正常妊娠区分开来方面具有临床潜力。
