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大鼠甲胎蛋白和白蛋白基因的多态性

Polymorphism of rat alphafetoprotein and albumin genes.

作者信息

Boulter J, Sell S

出版信息

Tumour Biol. 1984;5(6):365-70.

PMID:6085601
Abstract

Restriction endonuclease digestion using Hind III and Msp I and Southern blot analysis of DNA from the liver of three inbred rat strains and one outbred strain using cDNA probes yields two banding patterns for the alphafetoprotein and albumin genes. Buffalo and Fischer DNA have one pattern whereas ACI had a different pattern for both genes. Sprague Dawley DNA contains fragments of both patterns suggesting heterozygosity in some individuals of this strain. These polymorphisms do not appear to be associated with any structural or biological differences in the proteins resulting from expression of these genes.

摘要

使用Hind III和Msp I进行限制性内切酶消化，并使用cDNA探针对三种近交系大鼠品系和一种远交系大鼠品系肝脏中的DNA进行Southern印迹分析，结果显示甲胎蛋白和白蛋白基因呈现两种条带模式。布法罗大鼠和费希尔大鼠的DNA呈现一种模式，而ACI大鼠这两个基因的模式不同。斯普拉格-道利大鼠的DNA包含两种模式的片段，表明该品系某些个体存在杂合性。这些多态性似乎与这些基因表达所产生蛋白质的任何结构或生物学差异无关。

相似文献

1
Polymorphism of rat alphafetoprotein and albumin genes.大鼠甲胎蛋白和白蛋白基因的多态性
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2
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引用本文的文献

1
Methylation of the alphafetoprotein gene in cell populations isolated from rat livers during carcinogenesis.致癌过程中从大鼠肝脏分离的细胞群体中甲胎蛋白基因的甲基化
Nucleic Acids Res. 1985 Nov 25;13(22):8105-18. doi: 10.1093/nar/13.22.8105.